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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | |||
T74606 | A2A/A3 AR antagonist-1 | ||
Compound 23, designated as A2A/A3 AR antagonist-1, is a dual fluorescent ligand targeting A2A and A3 adenosine receptors (AR), exhibiting dissociation constants (Ki) of 90 nM for hA2A AR and 31.8 nM for hA3 AR, respectiv... | |||
T62134 | A1/A3 AR antagonist 1 | ||
A1/A3 AR antagonist 1 (Compound 10) is a potent, dual adenosine 1 (A1) and adenosine 3 (A3) receptor antagonist that acts on human A1 (Ki: 37.6 nM), human A3 (Ki: 25.4 nM) and rat A1 (Ki: 1.47 nM). 1 Can be used to study... | |||
T60732 | A2A/A1 AR antagonist-1 | ||
A2A/A1 AR antagonist-1 (compound 1a) has the potential for ischemic stroke research which is potent A 2A /A 1 AR dual antagonist with Ki s of 5.58 and 24.2 nM, respectively [1]. | |||
T9179 | CLP-3094 | 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE | Androgen Receptor |
CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP... | |||
T13273 | UT-34 | Androgen Receptor | |
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost... | |||
T60988 | Androgen receptor antagonist 4 | ||
Androgen receptor antagonist 4 (Compound AT2) has anticancer activities. Androgen receptor antagonist 4 potently antagonizes the activity of AR transcriptional, inhibits downstream target gene of AR, and blocks the DHT-i... | |||
T60719 | AR antagonist 3 | ||
When administered intratumorally, AR antagonist 3 shows effective inhibition on the growth of tumor. AR antagonist 3 is a potent and selective antagonist of androgen receptor (AR) with an IC 50 of 0.47 μM. AR antagonist ... | |||
T10320 | Androgen receptor antagonist 1 | Others | |
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP... | |||
T60987 | Androgen receptor antagonist 3 | ||
Androgen receptor antagonist 3 (Compound C18) has anticancer activities that is an antagonist of androgen receptor (AR) (IC 50 = 2.4 μM) [1]. | |||
T63960 | A3AR antagonist 1 | ||
A3AR antagonist 1 is a potent and selective human A3adenosine receptor (AR) antagonist (Ki: 4.63) and has no affinity for the rat A3AR. | |||
T61850 | Adenosine receptor inhibitor 1 | ||
Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >100... | |||
T79465 | Anticancer agent 135 | Androgen Receptor | |
Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 heterodimerization to suppress downstream gene transcription. ... | |||
T78811 | PROTAC AR-NTD degrader 1 | Androgen Receptor | |
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antago... | |||
T60687 | A1AR antagonist 1 | ||
A1AR antagonist 1 (compound 18g) is a potent antagonist of A1 adenosine receptor (AR). A1AR antagonist 1 has Ki values of 2.08, 6.91, and 31.2 nM for hA1, hA2A and hA2B, respectively [1]. | |||
T79027 | A1/A3 AR antagonist 3 | Adenosine Receptor | |
A1/A3 AR Antagonist 3 is a dual A1R/A3R antagonist that demonstrates high affinity within the low-micromolar to nanomolar range, and is potentially useful in the research of chronic heart diseases [1]. | |||
T78945 | WCA-814 | Androgen Receptor | |
WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in prostatic cancer cells with half maximal inhibitory concentratio... | |||
T60580 | A1AR antagonist 2 | ||
A1AR antagonist 2 (compound 18h) is a potent antagonist of the A1 adenosine receptor (AR). A1AR antagonist 2 has Ki values of 1.49, 10.2, and 50.1 nM for hA 1, hA 2A, and hA 2B, respectively [1]. | |||
T75702 | Galloylalbiflorin | ||
Galloylalbiflorin (6′-O-Galloylalbiflorin), an androgen receptor (AR) antagonist with an IC50 value of 53.3 μM, is a compound isolated from the roots of Paeonia lactiflora. It exhibits anti-androgen activity [1]. | |||
T9451 | Bopindolol | ||
Bopindolol is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol is a prodrug of pindolol... |